International Journal of Tuberculosis and Lung Disease
Volume 18, Issue 9, 2014, Pages 1085-1091

Molecular epidemiology and mapping of tuberculosis in Israel: Do migrants transmit the disease to locals? (Article)

Goldblatt D. , Rorman E. , Chemtob D. , Freidlin P.J.* , Cedar N. , Kaidar-Shwartz H. , Dveyrin Z. , Mor Z.
  • a National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, 69 Ben Tzvi Blvd, Tel-Aviv, 61082, Israel
  • b National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel
  • c Department of Tuberculosis and AIDS, Ministry of Health, Jerusalem, Israel
  • d National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, 69 Ben Tzvi Blvd, Tel-Aviv, 61082, Israel
  • e National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, 69 Ben Tzvi Blvd, Tel-Aviv, 61082, Israel
  • f National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, 69 Ben Tzvi Blvd, Tel-Aviv, 61082, Israel
  • g National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel
  • h Department of Tuberculosis and AIDS, Ministry of Health, Jerusalem, Israel, Ramla Department of Health, Ministry of Health, Ramla, Israel

Abstract

SETTING: Israel receives migrants from various countries, some of which have high tuberculosis (TB) prevalence. OBJECTIVE: To assess the predominant Mycobacterium tuberculosis strains in Israel isolated during 2008-2010 among Israeli-born and migrant patients, and to investigate possible transmission of TB from migrants to the local population. METHODS: Molecular characterisation employed 43-spacer spoligotyping and 16-loci mycobacterial interspersed repetitive units-variable number of tandem repeats typing. All patients were classified according to those who were members of a cluster and those who were not. RESULT S : Among 684 M. tuberculosis strains isolated from new patients genotyped and assigned to their specific cohort populations during the study period, major spoligotype families were Central Asian (CAS) (n = 140, 20%), Beijing (n = 101, 15%) and T (n = 160, 23%). Most Beijing strains (66%) were isolated from patients from the former Soviet Union (FSU), while CAS strains were mainly (74%) from Ethiopia, Eritrea and Sudan (EES). For the heterogeneous T-clade, patient countries of origin were 38% EES and 33% FSU. CONCLUSIONS: Predominant M. tuberculosis genotypes in Israel in 2008-2010 were similar to genotypes endemic to the migrants' countries of origin. Epidemiological investigations did not demonstrate transmission between migrants and Israeli-born patients sharing the same cluster. © 2014 The Union.

Author Keywords

transmission Migrants Genotyping tuberculosis Israel

Index Keywords

genetics genotype tandem repeat interspersed repeat China molecular biology Bacteriological Techniques disease classification Eritrea transmission molecular epidemiology Israel bacterium isolation predictive value human epidemiology controlled study time factor Mycobacterium tuberculosis priority journal Time Factors USSR nonhuman ethnology cluster analysis Humans migrant classification Adolescent male Emigrants and Immigrants female tuberculosis risk factor Risk Factors Infant contact examination prevalence Contact Tracing Article disease transmission Ethiopia major clinical study adult Molecular Diagnostic Techniques migration microbiological examination Predictive Value of Tests endemic disease molecular diagnosis microbiology cohort analysis Emigration and Immigration Central Asian bacterial strain Child Sudan
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906705258&doi=10.5588%2fijtld.14.0186&partnerID=40&md5=8fd39cdfe52154e3992ec265897c05f1
DOI: 10.5588/ijtld.14.0186
ISSN: 10273719
Cited by: 15
Original Language: English