Inflammatory Bowel Diseases
Volume 15, Issue 3, 2009, Pages 429-435

Epidemiology of Crohn's disease in Québec, Canada (Article)

Lowe A.-M. , Roy P.-O. , Poulin M.B. , Michel P. , Bitton A. , St-Onge L. , Brassard P.*
  • a Faculty of Medicine, University of Montréal, Montréal, QC, Canada
  • b Groupe de Recherche en Épidémiologie des Zoonoses et Sante Publique (GREZOSP), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada
  • c Groupe de Recherche en Épidémiologie des Zoonoses et Sante Publique (GREZOSP), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada, Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Saint-Hyacinthe, QC, Canada
  • d Groupe de Recherche en Épidémiologie des Zoonoses et Sante Publique (GREZOSP), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada, Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Saint-Hyacinthe, QC, Canada
  • e Faculty of Medicine, Division of Gastroenterology, McGill University Health Center (MUHC), 687 Pine Ave. West, Montréal, QC H3A 1A1, Canada
  • f Groupe de Recherche en Épidémiologie des Zoonoses et Sante Publique (GREZOSP), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada, Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Saint-Hyacinthe, QC, Canada
  • g Faculty of Medicine, University of Montréal, Montréal, QC, Canada, Faculty of Medicine, Division of Gastroenterology, McGill University Health Center (MUHC), 687 Pine Ave. West, Montréal, QC H3A 1A1, Canada

Abstract

Background: Crohn's disease (CD) is an idiopathic inflammatory bowel disease (IBD). We aimed to determine the prevalence and incidence of CD in Québec and characterize the demographic and health-related factors associated with this disease. Methods: We identified CD cases in the provincial administrative databases for the years 1993-2002. The CD prevalence and incidence rates were estimated respectively for the periods 1993-2002 and 1998-2000. We validated the identified cases using clinically confirmed IBD cases. Predictor variables of CD were analyzed using the Poisson regression model to explain the variation in CD incidence rates across Québec. Results: In all, 21,172 patients fulfilled the CD case definition for the period. The age and sex standardized average prevalence rate for 1993-2002 was 189.7 cases/100,000 population and the age and sex standardized incidence rate of CD for the 1998-2000 period was 20.2 cases/100,000 person-years. The female/male cases ratio among incident cases was 0.74 for the 0-14-year-old group, 1.30 for the 15-64-year-old group, and 1.77 for the cases older than 65 years old. After adjustment, independent predictors of CD incidence were: incidence of 5 reportable enteric diseases, proportion of individuals of Jewish ethnicity, and proportion of immigrant people. Conclusions: The identified predictors of CD explained 20% of the regional variance in the incidence rate of CD in the Québec population. Other factors such as genetic susceptibility to CD or the effect of an environmental cause should be taken into consideration in the models to explain the residual variance. Copyright © 2008 Crohn's & Colitis Foundation of America, Inc.

Author Keywords

Associated factors Crohn's disease Incidence Validation Prevalence

Index Keywords

immigrant survival rate Quebec sex ratio human trend study sex difference middle aged priority journal comparative study Aged morbidity prognosis crohn disease predictor variable Young Adult Humans Adolescent Infant, Newborn Canada male preschool child female Infant risk factor Jew Risk Factors Child, Preschool newborn population research prevalence Incidence Article Retrospective Studies major clinical study adult Sex Distribution age distribution ethnicity retrospective study Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-66149152708&doi=10.1002%2fibd.20756&partnerID=40&md5=d064e1d9a22af00aaa5aa09c0cea3923
DOI: 10.1002/ibd.20756
ISSN: 10780998
Cited by: 58
Original Language: English