Transplantation Proceedings
Volume 41, Issue 6, 2009, Pages 2363-2365

Renal Transplantation in Emigrants From Africa in Spain: Similar Results but Different Infectious Profile Compared With Spanish People (Article)

Mérida E. , Rodríguez A. , Hernandez G. , Huerta A. , Gonzalez J. , Hernández A. , González E. , Morales E. , Praga M. , Andrés A. , Morales J.M.*
  • a Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • b Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • c Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • d Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • e Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • f Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • g Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • h Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • i Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • j Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  • k Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain

Abstract

The number of renal transplantation of emigrants from Africa in Europe is increasing. However, there is little information about the results. The aim of this study was to compare the results of renal transplantation among this African emigrant population compared with a matched group of Spanish patients. From 1996-2006, 27 African emigrants (from Morocco, Guinea, and Nigeria) received renal transplants in Madrid. We compared their results with a matched cohort, including 69% who received a kidney from the same donors to 49 Caucasian Spanish patients. Demographic data were similar except that retransplantation was more frequent (32% vs 0%; P = .02) among Spanish patients and hepatitis B was more frequent among the African group (22% vs 2%; P = .004). For both groups the most frequent regimen was steroids, tacrolimus, and mycophenolate mofetil. Acute rejection incidence was similar (Africans 26% vs Spanish 22%), but rejection as a cause of graft loss was numerically more frequent in Africans (4 of 6). Patient and graft survival rates were identical in both groups (96% and 80%, respectively) at a mean follow-up of 76 months in Africans versus 68 months in Spanish people. Characteristically African patients required higher dose of tacrolimus to maintain the same levels; and notably, they suffered rare opportunistic infections, such as Phonopsis longicolla and visceral Leishmania. In summary, renal transplantation in African emigrant patients in Spain showed excellent results similar to those obtained with a Spanish population. However, these patients needed higher doseses of Tacrolimus and experienced more rare opportunistic infections. © 2009 Elsevier Inc. All rights reserved.

Author Keywords

[No Keywords available]

Index Keywords

Nigeria steroid Tissue Donors survival rate Caucasian race difference acute graft rejection graft failure follow up Guinea human middle aged Cohort Studies priority journal opportunistic infection Reoperation Young Adult immunosuppressive treatment Humans Treatment Outcome graft survival African Continental Ancestry Group Emigrants and Immigrants Spain visceral leishmaniasis Africa Incidence Article Retrospective Studies major clinical study adult migration Kidney Transplantation European Continental Ancestry Group postoperative complication hepatitis B mycophenolic acid 2 morpholinoethyl ester tacrolimus kidney graft rejection Morocco postoperative infection
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-68949201554&doi=10.1016%2fj.transproceed.2009.05.005&partnerID=40&md5=9eab72d88cde5e8e969fea0ae25d6565
DOI: 10.1016/j.transproceed.2009.05.005
ISSN: 00411345
Cited by: 1
Original Language: English