European Journal of Clinical Nutrition
Volume 63, Issue 9, 2009, Pages 1150-1153

Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants (Article) (Open Access)

Andersen R.* , Brot C. , Mejborn H. , Mølgaard C. , Skovgaard L.T. , Trolle E. , Ovesen L.
  • a Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark
  • b Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark
  • c Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark
  • d Department of Human Nutrition, Faculty of Life Science, University of Copenhagen, Frederiksberg, Denmark
  • e Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
  • f Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark
  • g Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark

Abstract

Potential long-term negative effects of increased vitamin D consumption are not thoroughly examined. The aim of this study was to investigate possible negative effects of vitamin D supplementation on serum lipids and lipoproteins. A 1-year long randomised double-blinded placebo-controlled intervention study with two doses of vitamin D3 (10 and 20 μg/day) was carried out among 89 women (18-53 years of age) and 84 men (18-64 years of age) of Pakistani origin living in Denmark with low vitamin D status. This study did not find changes in total cholesterol, LDL-cholesterol, HDL-cholesterol, LDL-cholesterol/ HDL-cholesterol ratio, VLDL-cholesterol and triacylglycerol after daily supplementation with 10 or 20 μg vitamin D for 1 year. In conclusion, increasing the vitamin D intake by 10-20 μg per day for 1 year is safe for Pakistani immigrants with regards to serum lipids and lipoproteins.

Author Keywords

[No Keywords available]

Index Keywords

Pakistan immigrant controlled clinical trial clinical trial cholesterol blood level low density lipoprotein cholesterol dose response human double blind procedure middle aged Denmark Vitamin D lipoprotein blood level Dietary Supplements controlled study randomized controlled trial Dose-Response Relationship, Drug drug efficacy very low density lipoprotein cholesterol drug dose comparison Triglycerides Young Adult Humans treatment duration Adolescent male female colecalciferol Double-Blind Method placebo cholesterol vitamin D deficiency Article major clinical study adult drug safety vitamin supplementation high density lipoprotein cholesterol triacylglycerol blood level triacylglycerol outcome assessment age distribution drug dose increase nutritional status
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-70249151102&doi=10.1038%2fejcn.2009.18&partnerID=40&md5=6e4445bc98ec03ffcde3c008c90c7038
DOI: 10.1038/ejcn.2009.18
ISSN: 09543007
Cited by: 35
Original Language: English