Netherlands Heart Journal
Volume 17, Issue 4, 2009, Pages 155-161

Cardiovascular risk in young apparently healthy descendents from Asian Indian migrants in the Netherlands: The SHIVA study (Article)

Liem S.S. , Oemrawsingh P.V. , Cannegieter S.C. , Le Cessie S. , Schreur J. , Rosendaal F.R. , Schalij M.J.
  • a Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
  • b Department of Cardiology, Medical Center Haaglanden, The Hague, Netherlands
  • c Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
  • d Department of Medical Statistics, Leiden University Medical Center, Leiden, Netherlands
  • e Department of Cardiology, Medical Center Haaglanden, The Hague, Netherlands
  • f Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
  • g Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands

Abstract

Background. Asian Indian migrants in the Western world are highly susceptible for ischaemic heart disease (IHD). Until now, most IHD risk studies were performed in first and second generation Asian Indian expatriates. For optimal prevention, knowledge of the cardiovascular risk profile of younger generations is crucial. Method. In a cross-sectional study we assessed the prevalence of conventional IHD risk factors and Framingham risk score in asymptomatic third to seventh generation Asian Indian descendants, compared with Europeans. Subjects were classified as asymptomatic if they did not have documented IHD, diabetes, hypertension or high cholesterol. Results. A total of 1790 Asian Indians (45% men, age 35.9±10.7 years) and 370 native Dutch hospital employees (23% men, age 40.8±10.1 years) were recruited. Asian Indians had higher levels of total cholesterol, low-density lipoprotein, triglycerides, and lower high-density lipoprotein levels than the Dutch. Glucose intolerance was present in 7.1 vs. 0.5% men, and in 6.1 vs. 1.4% women (both p<0.001). Asian Indian women were more frequently obese (12 vs. 5%; plt;0.001), and centrally obese (44 vs. 25%; p<0.001) as compared with the Dutch women. Prevalence of most of the conventional and modifiable cardiovascular risk factors in each ten-year age group was higher in Asian Indians compared with controls, which reflected in higher Framingham risk scores. Conclusion. This study demonstrates the persistence of an unfavourable cardiovascular risk profile in young, third to seventh generation migrated Asian Indians and supports an aggressive screening and intervention strategy.

Author Keywords

Framingham risk score cardiovascular risk Asian Indians

Index Keywords

Netherlands immigrant hypercholesterolemia progeny cardiovascular risk Caucasian cholesterol blood level low density lipoprotein cholesterol Indian human diabetes mellitus controlled study obesity comparative study hypertension screening ethnic difference male female prevalence glucose intolerance cholesterol Article scoring system glucose blood level major clinical study adult high density lipoprotein cholesterol triacylglycerol blood level triacylglycerol ischemic heart disease glucose normal human
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349292187&doi=10.1007%2fBF03086238&partnerID=40&md5=4f5d826d848a2b785bd47447b35bb331
DOI: 10.1007/BF03086238
ISSN: 15685888
Cited by: 9
Original Language: English