PLoS ONE
Volume 9, Issue 5, 2014

A population-based study examining hepatitis B virus infection and immunization rates in northwest China (Article) (Open Access)

Ji Z. , Wang T. , Shao Z. , Huang D. , Wang A. , Guo Z. , Long Y. , Zhang L. , Su H. , Zhang Q. , Yan Y. , Fan D.
  • a Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • b Wuwei Municipal Center for Disease Control and Prevention, Gansu, China
  • c Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • d Wuwei Municipal Center for Disease Control and Prevention, Gansu, China
  • e Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • f Wuwei Municipal Center for Disease Control and Prevention, Gansu, China
  • g Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • h Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • i Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • j Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • k Department of Epidemiology, School of Public Health, Fourth Military Medical University, Xi'an, China
  • l Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China

Abstract

Background and Aim: Current baseline data regarding the prevalence of hepatitis B virus (HBV) infections and the immune status in hyperendemic areas is necessary in evaluating the effectiveness of ongoing HBV prevention and control programs in northwest China. This study aims to determine the prevalence of chronic HBV infections, past exposure rates, and immune response profiles in Wuwei City, northwest China in 2010. Methods: Cross-sectional household survey representative of the Wuwei City population. 28,579 participants were interviewed in the seroepidemiological survey ≥1 year of age. House to house screening was conducted using a standard questionnaire. All serum samples were screened by enzyme-linked immunoassays for the presence of hepatitis B surface antigen, antibodies against HBV surface antigen, and antibodies to the hepatitis B core antigen. Results: Among individuals ≥1 year of age, 7.2% (95%CI: 6.3-8.1%) had chronic HBV infections, 43.9% (CI: 40.4-47.4%) had been exposed to HBV, and 23.49% (CI: 21.6-25.3%) had vaccine-induced immunity. Multi-factor weighted logistic regression analysis showed that having household contact with HBV carriers (OR = 2.6, 95%CI: 2.3-3.0) and beauty treatments in public places (OR = 1.2, 95%CI: 1.1-1.3) were the risk factors of HBV infection in whole population. Having household contact with HBV carriers (OR = 3.8, 95% CI: 2.2-6.5) and lack of hepatitis vaccination (OR = 2.0, 95% CI: 1.4-3.3) were the risk factors for HBV infection in children aged 1-14 years. Conclusions: Hepatitis B infection remains a serious public health problem in northwest China. Having household contact with HBV carriers and beauty treatments in public places represented HBV infection risk factors. Hepatitis B vaccine immunization strategies need further improvement, particularly by targeting the immunization of rural migrant workers. © 2014 Ji et al.

Author Keywords

[No Keywords available]

Index Keywords

China human middle aged statistics and numerical data rural population Aged Logistic Models Hepatitis B virus Cross-Sectional Studies Young Adult cross-sectional study Humans virology Adolescent male preschool child heterozygote Infant preventive health service risk factor enzyme linked immunosorbent assay Risk Factors Child, Preschool female questionnaire population research immunology prevalence Article blood Questionnaires Hepatitis B Vaccines adult migration infection risk immune response hepatitis B vaccine hepatitis B surface antigen public health problem statistical model Immunization Programs Transients and Migrants vaccination hepatitis B Enzyme-Linked Immunosorbent Assay Hepatitis B Surface Antigens Seroepidemiologic Studies virus carrier immunization immune status hepatitis antibody hepatitis B core antigen Carrier State Hepatitis B Core Antigens Hepatitis Antibodies Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901309440&doi=10.1371%2fjournal.pone.0097474&partnerID=40&md5=93dcdf6b93c7d73af441f71f38017125
DOI: 10.1371/journal.pone.0097474
ISSN: 19326203
Cited by: 21
Original Language: English