Epidemiologia e Prevenzione
Volume 33, Issue 1-2, 2009, Pages 45-50

Skin cancer risk factors in childhood: Findings of a survey in an italian area characterized by an atypical migration [Infanzia e fattori di rischio per tumori della cute: Risultati di un'indagine in un'area italiana oggetto di una migrazione atipica] (Review)

Ramazzotti V.* , Terrenato I. , Catricala C. , Pannozzo F. , Natali M. , Natali P.G. , Cercato M.C.
  • a Struttura Complessa di Epidemiologia, Istituto Nazionale Tumori Regina Elena, Istituti Fisioterapici Ospitalieri, Via E. Chianesi 53, 00144 Roma, Italy
  • b Struttura Complessa di Epidemiologia, Istituto Nazionale Tumori Regina Elena, Istituti Fisioterapici Ospitalieri, Via E. Chianesi 53, 00144 Roma, Italy
  • c Struttura Complessa di Denmatologia Oncologics, Istituto Dermatologico Santa Maria and San Gallicano, Istituti Fisioterapici Ospitalieri, Roma, Italy
  • d Registro Tumori di Popolazione della Provincia di Latina, Azienda Unità Sanitaria Locale, Latina, Italy
  • e Divisione di Oncologia, Ospedale-S. Maria Gorettfr, Azienda Unità Sanitaria Locale, Latina, Italy
  • f Laboratorio di Immunologia, Istituto Nazionale Tumori Regina Elena, Istituti Fisioterapici Ospitalieri, Roma, Italy
  • g Struttura Complessa di Epidemiologia, Istituto Nazionale Tumori Regina Elena, Istituti Fisioterapici Ospitalieri, Via E. Chianesi 53, 00144 Roma, Italy

Abstract

Objective: to evaluate the association of different phenotypes with sun sensitivity factors, sun protection behavior and ethnicity in school-age children. Design: cross sectional study in the framework of a survey of children using a self-administered questionnaire. Setting and participants: 35412 children attending primary schools in the provinces of Latina and Rome, located in the Lazio region (Italy), in the 1998-2001 time period. Main outcome measures: Odds Ratios (ORs) and their relative 95% Confidence Intervals (95% CI) computed through univariate and multivariate logistic regression models. Results: FOTO positives phenotype, a proxy variable of the fair phenotype, was directly and significantly associated with the tendency to sunburn (OR 4.64;95% CI 4.39-4.89), the presence of freckles on the face (OR 1.65;95% CI 1.55-1.77), ofnaevi on the left forearm (OR 1.18;95% CI 1.12-1.25), the number of grandparents born in northern areas (OR 1.54;95% CI 1.15-2.07, for four northern grandparents versus none), the residence in Latina Province (OR 1.13;95% CI 1.07-1.20) and the use of sunscreens (OR 1.70;95% CI 1.55-1.88). An inverse association was observed with the male sex (OR 0.91;95% CI0.86-0.96), the increase of school-class level (OR 0.66;95% CI 0.61-0.72, for the highest versus the lowest school-class level) and the ability to tan (OR 0.38;95% CI 0.34-0.42). Conclusion: These findings confirmed that fairness of phenotype is associated in children with other skin cancer risk factors as well as ethnicity and parents' sun protection behavior.

Author Keywords

Skin neoplasms Sunscreening agents Melanoma risk factors child

Index Keywords

genetics residential mobility multicenter study clinical trial health survey risk human Odds Ratio statistics Confidence Intervals Logistic Models Health Surveys Cross-Sectional Studies Confidence interval student cross-sectional study Humans male female risk factor Risk Factors Multivariate Analysis questionnaire Skin Neoplasms Article Sunburn Questionnaires migration skin pigmentation Italy Analysis of Variance Students statistical model skin tumor sunscreen Sunscreening Agents phenotype Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-68549112844&partnerID=40&md5=5f9a91e4c7012c7e3e0f86fe9bb506f5
ISSN: 11209763
Cited by: 1
Original Language: Italian