Rheumatology (Oxford, England)
Volume 48, Issue 11, 2009, Pages 1392-1397

Impact of immigration on the clinical expression of systemic lupus erythematosus: a comparative study of Hispanic patients residing in the USA and Mexico. (Article) (Open Access)

Uribe A.G.* , Romero-Díaz J. , Apte M. , Fernández M. , Burgos P.I. , Reveille J.D. , Sánchez-Guerrero J. , Alarcón G.S.
  • a Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • b Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • c Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • d Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • e Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • f Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • g Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico
  • h Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zurbirán, Mexico City, Mexico

Abstract

OBJECTIVE: To compare the socio-economic characteristics, clinical features and health-related quality of life in Hispanic SLE patients residing in Mexico and in the Southwest USA (Mexican and Texan, herein). METHODS: Mexican and Texan SLE patients (fulfilling ACR criteria) participating in separate longitudinal outcome studies were evaluated. Texan patients were randomly chosen to match total disease duration with the Mexican patients. Cross-sectional data for the Mexican patients were obtained by a US-trained investigator who had previously participated in data collection for the cohort to which the Texan patients belonged. Socio-economic and -demographic characteristics, clinical characteristics, disease activity (with SLAM-Revised), damage accrual (with SLICC/ACR Damage Index) and self-reported function (with Short Form-36) were compared between the two groups. RESULTS: Seventy Mexican patients were matched with either one or two Texan patients (n = 94) for a total of 164 patients. Mexican patients were younger. In age-adjusted analyses, the Mexican patients were more educated, had better health-related quality of life and overall less systemic SLE manifestations. Mexican patients were exposed more frequently to AZA. CONCLUSIONS: Texan patients had more severe disease than the Mexican patients. In multivariable analyses, Texan Hispanic ethnicity was significantly associated with high disease activity, but significance was not reached for damage. The discrepant findings observed between these two Hispanic groups of SLE patients may reflect socio-economic or biological factors. Given the global phenomenon of immigration, rheumatologists should be aware of the overall course and outcome of immigrant SLE patients if undesirable outcomes are to be prevented.

Author Keywords

[No Keywords available]

Index Keywords

educational status hospitalization multicenter study clinical trial demography human statistics comparative study ethnology Mexico Hispanic Americans Residence Characteristics Cross-Sectional Studies quality of life Young Adult drug utilization United States cross-sectional study Humans Hispanic Adolescent Severity of Illness Index male female Socioeconomic Factors socioeconomics Article adult migration systemic lupus erythematosus Lupus Erythematosus, Systemic Emigration and Immigration Texas
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-73349093416&doi=10.1093%2frheumatology%2fkep266&partnerID=40&md5=8dca35bc7a40cff1a1cdecf5b06d67d6
DOI: 10.1093/rheumatology/kep266
ISSN: 14620332
Cited by: 10
Original Language: English