Retrovirology
Volume 5, 2008

Isolation of a new HIV-2 group in the US (Article) (Open Access)

Smith S.M.* , Christian D. , de Lame V. , Shah U. , Austin L. , Gautam R. , Gautam A. , Apetrei C. , Marx P.A.
  • a Division of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ 07102, United States
  • b Division of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ 07102, United States
  • c Division of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ 07102, United States
  • d Division of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ 07102, United States
  • e Division of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ 07102, United States
  • f Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, United States
  • g Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, United States
  • h Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, United States, Department of Tropical Medicine, School of Public Health, Tulane University, New Orleans, LA 70112, United States
  • i Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, United States, Department of Tropical Medicine, School of Public Health, Tulane University, New Orleans, LA 70112, United States

Abstract

Human immunodeficiency virus type 2 (HIV-2) emerged following cross-species transmission of simian immunodeficiency virus (SIV) from sooty mangabeys to humans several decades ago. The epidemic groups of HIV-2 have been established in the human population for at least 50 years. However, it is likely that new divergent SIVs can infect humans and lead to new outbreaks. We report the isolation of a new strain of HIV-2, HIV2-NWK08F, from an immunodeficient Sierra Leone immigrant. Health care providers in Sierra Leone and elsewhere need to be alerted that a subtype of HIV-2, which is not detected by PCR for epidemic HIV-2 strains, exists and can lead to immunosuppression. © 2008 Smith et al; licensee BioMed Central Ltd.

Author Keywords

[No Keywords available]

Index Keywords

genetics immigrant CD4 CD8 ratio Human immunodeficiency virus 2 antibody blood level HIV Infections Human immunodeficiency virus infection virus strain human structural gene Aged Sierra Leone virus isolation United States immunosuppressive treatment Humans virus detection classification virology Human immunodeficiency virus antibody male CD4 lymphocyte count case report Genes, gag Simian immunodeficiency virus enzyme linked immunosorbent assay polymerase chain reaction isolation and purification Communicable Diseases, Emerging Article disease transmission immunoblotting HIV-2 communicable disease Phylogeny virus load virus transmission
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-57649232768&doi=10.1186%2f1742-4690-5-103&partnerID=40&md5=9da5f5368e797a067bf5d5d75e17257f
DOI: 10.1186/1742-4690-5-103
ISSN: 17424690
Cited by: 17
Original Language: English