British Journal of Nutrition
Volume 100, Issue 1, 2008, Pages 197-207

Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: A randomised double-blinded placebo-controlled intervention study (Article) (Open Access)

Andersen R.* , Mølgaard C. , Skovgaard L.T. , Brot C. , Cashman K.D. , Jakobsen J. , Lamberg-Allardt C. , Ovesen L.
  • a Department of Nutrition, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark
  • b Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
  • c Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
  • d Department of Nutrition, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark
  • e Department of Food and Nutritional Sciences, University College Cork, Cork, Ireland
  • f Department of Chemistry, National Food Institute, Technical University of Denmark, Søborg, Denmark
  • g Division of Nutrition, University of Helsinki, Helsinki, Finland
  • h Department of Nutrition, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark

Abstract

Severe vitamin D deficiency is common among Muslim immigrants. The dose necessary to correct the deficiency and its consequence for bone health are not known for immigrants. The aim was to assess the effect of relatively low dosages of supplemental vitamin D on vitamin D and bone status in Pakistani immigrants. This 1-year-long randomised double-blinded placebo-controlled intervention with vitamin D3 (10 and 20 μg/d) included girls (10.1-1.7 years), women (18.1-52.7 years) and men (17.9-63.5 years) of Pakistani origin living in Denmark. The main endpoints were serum 25-hydroxyvitamin D (S-25OHD), parathyroid hormone, bone turnover markers and bone mass. The study showed that supplementation with 10 and 20 μg vitamin D3 per d increased S-25OHD concentrations similarly in vitamin D-deficient Pakistani women (4-fold), and that 10 μg increased S-25OHD concentrations 2-fold and 20 μg 3-fold in Pakistani men. S-25OHD concentrations increased at 6 months and were stable thereafter. Baseline S-25OHD concentrations tended to be lower in girls and women than in men; females achieved about 46 nmol/l and men 55 nmol/l after supplementation. Serum intact parathyroid hormone concentrations decreased at 6 months, but there was no significant effect of the intervention on bone turnover markers and dual-energy X-ray absorptiometry measurements of the whole body and lumbar spine. © The Authors 2008.

Author Keywords

Pakistani immigrants Bone turnover randomised controlled trials Bone mass Vitamin D intervention

Index Keywords

dual energy X ray absorptiometry Pakistan immigrant bone turnover controlled clinical trial clinical trial human double blind procedure middle aged Denmark Vitamin D controlled study randomized controlled trial Dose-Response Relationship, Drug Aged Young Adult school child parathyroid hormone Humans Adolescent 25 hydroxyvitamin D male Emigrants and Immigrants female colecalciferol Double-Blind Method bone mass placebo vitamin D deficiency Article intervention study adult Bone Density Sex Factors Age Factors vitamin supplementation whole body imaging Cholecalciferol bone structure Amino Acids Osteocalcin lumbar spine Bone and Bones Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-53049110450&doi=10.1017%2fS000711450789430X&partnerID=40&md5=f7ef8a6342ec337cf99e5820466cca77
DOI: 10.1017/S000711450789430X
ISSN: 00071145
Cited by: 50
Original Language: English