Respiratory Medicine
Volume 102, Issue 6, 2008, Pages 919-926

The effect of ethnic origin on pulmonary prediction equations in a Jewish immigrant population (Article) (Open Access)

Steinvil A. , Fireman E. , Wolach O. , Rebhun U. , Cohen M. , Shapira I. , Berliner S. , Rogowski O.*
  • a Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel
  • b Institute for Pulmonary and Allergic Disease, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel
  • c Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel
  • d Division of Jewish Demography and Statistics, The A Harman Institute of Contemporary Jewry, The Hebrew University of Jerusalem, Jerusalem, Israel
  • e Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel
  • f Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel
  • g Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel
  • h Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel

Abstract

Background: Ethnic origin affects spirometric prediction values. Our aims were to investigate the effect of ethnic origin on prediction equations in an immigrant-based society, identify possible deviations from commonly used prediction equations and analyze the effect of miscalculation in a large cohort of apparently healthy individuals. Methods: Healthy never-smokers participants from a large Israeli survey underwent lung function testing and were divided into two major ethnic groups: Ashkenazi Jews (AJ) and Sephardic Jews (SJ). Data were analyzed by multiple linear regressions. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC ratio were measured according to ERS-ATS guidelines. Results: The study population comprised 3150 individuals (AJ=1817; SJ=1333). AJ tended to be older and taller than SJ (all p<0.005). Ethnicity entered as a significant regression variable for FVC for both genders and for FEV 1 for females only. The final regression model for both FVC and FEV 1 had R 2 =0.71 and the standard error of the estimate (SEE) for FVC and FEV 1 were 0.54 and 0.43 L, respectively. The regression model for the FEV 1 /FVC ratio has less statistical strength (R 2 =0.06, SEE=6.15%). We found statistically significant underestimates of predicted lung volumes from the commonly used prediction equation for each ethnic group. Conclusions: Ashkenazi and Sephardic Jews have different ranges of normal pulmonary function values. Lung function prediction equations in an immigrant-based society should be based on local and not previously reported regional equations and adjusted for ethnic attributed variance. © 2008 Elsevier Ltd. All rights reserved.

Author Keywords

Pulmonary function testing Forced expiratory volume Ethnicity Forced vital capacity Prediction equations

Index Keywords

Israel society Vital Capacity human lung function forced expiratory volume immigration aging lung function test middle aged controlled study priority journal Aged spirometry error Humans lung volume male female Aged, 80 and over multiple linear regression analysis Jew Jews Article prediction and forecasting adult gender Predictive Value of Tests cohort analysis normal human ethnicity body height health survey
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-43049144203&doi=10.1016%2fj.rmed.2007.12.028&partnerID=40&md5=9b599a9a7d1e8bc2f38634e423c8aa3d
DOI: 10.1016/j.rmed.2007.12.028
ISSN: 09546111
Cited by: 4
Original Language: English