Objectives. We examined whether immigration-related characteristics and perceptions of risk surrounding substance use were independently associated with lifetime use of cigarettes and various illicit substances among immigrant and native-born Latino and non-Latino White adults in the United States. Methods. Data were from the 2002 National Survey on Drug Use and Health. Analyses were limited to Latinos and non-Latino Whites 18 years and older. We used cross-tabulations and multivariate logistic regression to test relations between risk perceptions, immigration characteristics, and substance use. Results. More than two thirds of all respondents perceived moderate or great risk to health and well-being associated with all substances analyzed. The odds of lifetime substance use by Latino and non-Latino White immigrants were lower than for US-born non-Latino Whites. Immigrant Latinos' odds of lifetime substance use were lower than for US-born Latinos. Moderate or great perceived risk was associated with lower likelihood of lifetime use of all substances except cigarettes. Conclusions. Foreign birth appeared to protect against substance use among both Latino and non-Latino White immigrants. Future studies should examine potential protective factors, including cultural beliefs and practices, acculturation, familial ties, and social network influences.

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methodology Caucasian race difference Population Surveillance human immigration middle aged statistics controlled study Cigarette Smoking Substance-Related Disorders Aged substance abuse Logistic Models Hispanic Americans United States Humans Hispanic classification smoking male Emigrants and Immigrants Adolescent female prevalence Marijuana Smoking Article high risk behavior Risk-Taking health care major clinical study adult migration European Continental Ancestry Group addiction ethnicity statistical model cannabis smoking health survey