Journal of Paediatrics and Child Health
Volume 44, Issue 4, 2008, Pages 166-169

High perinatal seroprevalence of cytomegalovirus in northern Taiwan (Article)

Chen M.-H. , Chen P.-C. , Jeng S.-F. , Hsieh C.-J. , Su F.-C. , Liao H.-F. , Su Y.-N. , Lin S.-J. , Hsieh W.-S.*
  • a Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
  • b Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
  • c School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan
  • d Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
  • e Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
  • f School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan
  • g Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan, Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
  • h Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan
  • i Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, Taipei, Taiwan

Abstract

Aim: The living style, health-care system and socio-economic environments have changed substantially in Taiwan over past 20 years. This study was aimed to estimate the current perinatal cytomegalovirus (CMV) seroprevalence in northern Taiwan. Methods: In a Taiwan Birth Panel Study, 483 pairs of mothers and neonates were prospectively recruited from one tertiary medical center, one local hospital, and two obstetric clinics located in northern Taiwan from April 2004 through January 2005. Sera of their paired maternal and cord blood were tested by an enzyme-linked immunosorbent assay method for CMV IgG and IgM antibodies. Additional data were collected for health measures and epidemiological characteristics through trained interviewers utilising structured questionnaires. Results: Among 483 mothers studied, 93% were Taiwanese, 6.4% were immigrants from the south-eastern Asia and Mainland China, and 0.6% was aborigines. The seropositive rate of CMV IgG and IgM among the mothers was 91.1% and 3.5%, respectively. The immigrant mothers and the mothers younger than 20 years of age had a higher IgM seroprevalence (P < 0.05). Furthermore, 90.8% of the offspring had CMV IgG seropositivity and yet none of the neonates were CMV IgM positive. Conclusion: The seroprevalence of CMV among childbearing women is high in northern Taiwan. The immigrant mothers and the teenage mothers appear to have higher seropositivity of CMV IgM. © 2007 The Authors.

Author Keywords

Perinatal Cytomegalovirus Taiwan Seroprevalence

Index Keywords

cytomegalovirus infection prospective study immigrant progeny Antibodies, Viral Pregnancy Complications, Infectious human priority journal maternal serum Taiwan Humans antibody detection Adolescent Infant, Newborn male Cytomegalovirus Infections female Cytomegalovirus antibody Aborigine enzyme linked immunosorbent assay Risk Factors newborn questionnaire pregnancy umbilical cord blood Incidence Article major clinical study adult immunoglobulin M antibody immunoglobulin G antibody structured interview Fetal Blood seroprevalence immunoglobulin G Seroepidemiologic Studies Cytomegalovirus Pilot Projects immunoglobulin M Enzyme-Linked Immunosorbent Assay
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-41549138788&doi=10.1111%2fj.1440-1754.2007.01215.x&partnerID=40&md5=169d98764ca7397cffcf2130079db801
DOI: 10.1111/j.1440-1754.2007.01215.x
ISSN: 10344810
Cited by: 27
Original Language: English