Leukemia and Lymphoma
Volume 58, Issue 4, 2017, Pages 959-968

Risk of Hodgkin lymphoma according to immigration status and origin: a migrant cohort study of 2.3 million Jewish Israelis (Article)

Levine H.* , Leiba M. , Bar Zeev Y. , Keinan-Boker L. , Derazne E. , Leiba A. , Kark J.D.
  • a Hebrew University-Hadassah Braun School of Public Health and Community Medicine, Jerusalem, Israel, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  • b Multiple Myeloma Service, Division of Hematology, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
  • c Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
  • d The National Cancer Registry, Israel Center for Disease Control, Ministry of Health, Jerusalem, Israel, School of Public Health, University of Haifa, Haifa, Israel
  • e Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel, The Israel Defense Forces Medical Corps, Jerusalem, Israel
  • f Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel, The Israel Defense Forces Medical Corps, Jerusalem, Israel, Department of Medicine and Medical Education, Mount Auburn Hospital, Harvard Medical School, Boston, MA, United States
  • g Hebrew University-Hadassah Braun School of Public Health and Community Medicine, Jerusalem, Israel

Abstract

Hodgkin Lymphoma (HL), a common early adulthood malignancy, has a complex etiology. We conducted a migrant cohort study to assess immigration status and origin as predictors of HL in Israel, which has among the highest rates of HL worldwide. Nationwide data on 2,285,009 16–19-year-old Jewish adolescents, collected from 1967–2011, were linked to Israel’s Cancer Registry to obtain the incidence of HL until 2012. Two thousand and ninety-three HL cases were detected during 47.0 million person-years of follow-up. Using multivariable-adjusted Cox proportional hazards modeling, risk was higher for Israeli-born compared to immigrants, similarly across origin groups (HR = 1.59; 95%CI 1.32–1.92 for the dominant nodular sclerosis subtype). Risk of HL was greater for more recent year of birth, higher BMI, taller stature, and apparently for women. These findings suggest that exposure to as yet unidentified elements of the Israeli environment increase the risk of nodular sclerosis HL, and should aid in directing research efforts. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Author Keywords

life course epidemiology Migration Hodgkin lymphoma Stress young adults Environment

Index Keywords

Israel Registries anthropometric parameters Population Surveillance register follow up human Israeli clinical assessment middle aged immigration sex difference risk assessment controlled study priority journal comparative study cancer risk Aged Young Adult Humans migrant Adolescent male Emigrants and Immigrants female Socioeconomic Factors nodular sclerosis Hodgkin lymphoma risk factor Risk Factors environmental exposure socioeconomics high risk population Hodgkin disease Incidence Article major clinical study adult migration age Sex Factors Age Factors outcome assessment cohort analysis Emigration and Immigration cancer diagnosis body mass body height disease association sex cancer incidence health survey
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983516653&doi=10.1080%2f10428194.2016.1220552&partnerID=40&md5=e390cb2060b2a0240c928832cf4ee20d
DOI: 10.1080/10428194.2016.1220552
ISSN: 10428194
Cited by: 2
Original Language: English