Journal of Acquired Immune Deficiency Syndromes
Volume 76, Issue 4, 2017, Pages 343-347

Feasibility, acceptability, and adherence with short-term HIV preexposure prophylaxis in female sexual partners of migrant miners in Mozambique (Article)

Lahuerta M.* , Zerbe A. , Baggaley R. , Falcao J. , Ahoua L. , Di Mattei P. , Morales F. , Ramiro I. , El-Sadr W.M.
  • a ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States
  • b ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States
  • c HIV Department, World Health Organization, Geneva, Switzerland
  • d ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States
  • e ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States
  • f ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States
  • g ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States
  • h Ministry of Health, Maputo, Mozambique
  • i ICAP, Columbia University, Mailman School of Public Health, New York, NY 10032, United States, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States

Abstract

Background: Preexposure prophylaxis (PrEP) offers protection from HIV acquisition if taken as prescribed. We evaluated the feasibility, acceptability, and adherence with short-term PrEP among female sexual partners of migrant miners in Mozambique. Methods: HIV-negative female sexual partners of migrant miners were offered daily tenofovir/emtricitabine (TDF/FTC) for 6 weeks concurrent with miners' return home. Study visits occurred at baseline, week 4, 6, and 8. Dried blood spots (DBSs) were collected at week 4 and 6. Results: Seventy-four women (median age: 42 years) were enrolled, 95% reported having 1 sexual partner and 80% reported never or rarely using condoms. At baseline, 41% had never tested for HIV; 65% were unaware of partners' HIV status. Of all women, 72 (97%) initiated PrEP, 7 (9%) discontinued PrEP before week 6; only 1 due to adverse events. Missed doses in the last week were self-reported by 8% and 3% of women at week 4 and 6, respectively. Of 66 (89%) women with DBS at week 4, 79% had detectable tenofovir diphosphate (TFV-DP) and 44% had levels consistent with $4 pills/wk ($700 fmol/punch). Of 63 (88%) women with DBS at week 6, 76% had detectable TFV-DP and 42% had levels consistent with $4 pills/wk. Conclusions: In this first study assessing the use of short-term PrEP, a high percent of female partners of migrant workers initiated PrEP and had detectable DP levels during follow-up. Further efforts are needed to enhance adherence to ensure protection from HIV acquisition. Short-term PrEP offers promise for populations who are at high risk of HIV during specific periods of time. Copyright © 2017 The Author(s).

Author Keywords

Female partners of miners Preexposure prophylaxis Short-term migrant Mozambique

Index Keywords

educational status HIV Infections sexual behavior Human immunodeficiency virus infection chronopharmacology follow up human epidemiology sexuality middle aged Sexual Partners Self Report statistics and numerical data condom Condoms priority journal medication compliance mining Feasibility Studies dizziness condom use migrant worker Humans treatment duration psychology headache female Medication Adherence Mozambique short course therapy Health Knowledge, Attitudes, Practice pill emtricitabine Article feasibility study gastrointestinal symptom manpower tenofovir patient compliance Directive Counseling drug withdrawal adult migration infection prevention major clinical study miner utilization patient attitude Patient Acceptance of Health Care Transients and Migrants treatment withdrawal dried blood spot testing Fatigue attitude to health pre-exposure prophylaxis anti human immunodeficiency virus agent Anti-HIV Agents
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038561994&doi=10.1097%2fQAI.0000000000001518&partnerID=40&md5=efe7e48d5d9db4d757f7048b59c3971d
DOI: 10.1097/QAI.0000000000001518
ISSN: 15254135
Cited by: 3
Original Language: English