Transplant Infectious Disease
Volume 12, Issue 4, 2010, Pages 371-374

Invasive filamentous fungal infections associated with renal transplant tourism: Short communication (Article)

Shoham S.* , Hinestrosa F. , Moore Jr. J. , O'Donnell S. , Ruiz M. , Light J.
  • a Section of Infectious Diseases, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, United States
  • b Section of Infectious Diseases, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, United States
  • c Section of Nephrology, Washington Hospital Center, Washington, DC, United States
  • d Section of Vascular and Endovascular Surgery, United States
  • e Section of Infectious Diseases, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, United States
  • f Transplantation Services, Washington Hospital Center, Washington, DC, United States

Abstract

'Transplant tourism,' the practice of traveling abroad to acquire an organ, has emerged as an issue in kidney transplantation. We treated a patient who developed invasive aspergillosis of the allograft vascular anastomosis after receiving a kidney transplant in Pakistan, prompting us to review the literature of invasive mycoses among commercial organ transplant recipients. We reviewed all published cases of infections in solid organ transplant recipients who bought their organs abroad and analyzed these reports for invasive fungal infections. Including the new case reported here, 19 cases of invasive fungal infections post commercial kidney transplant occurring in 17 patients were analyzed. Infecting organisms were Aspergillus species (12/19; 63%), Zygomycetes (5/19; 26%), and other fungi (2/19; 5%). Invasive mold infections were present at the transplanted graft in 6/17 patients (35%) with graft loss or death in 13/17 (76%) of patients and overall mortality (10/17) 59%. Invasive fungal infections, frequently originating at the graft site, have emerged as a devastating complication of commercial renal transplant and are associated with high rates of graft loss and death. © 2010 John Wiley & Sons A/S.

Author Keywords

fungal Transplant aspergillosis invasive fungal infections mucormycosis Transplant tourism commercial Kidney transplant

Index Keywords

Aspergillus Fungi Pakistan kidney donor tourism graft failure human Asia Middle East travel priority journal Aged systemic mycosis transplant tourism death Commerce Humans donor selection male Mycoses case report clinical article Article kidney graft graft recipient Kidney Transplantation mucormycosis aspergillosis mortality invasive aspergillosis Zygomycetes voriconazole blood vessel shunt
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955931650&doi=10.1111%2fj.1399-3062.2010.00498.x&partnerID=40&md5=60ffcaeaa2f0768acb0d0e4e4add2143
DOI: 10.1111/j.1399-3062.2010.00498.x
ISSN: 13982273
Cited by: 27
Original Language: English