Transplantation
Volume 89, Issue 12, 2010, Pages 1456-1461

Organ trafficking for live donor kidney transplantation in indoasians resident in the west midlands: High activity and poor outcomes (Article)

Krishnan N.* , Cockwell P. , Devulapally P. , Gerber B. , Hanvesakul R. , Higgins R. , Ready A. , Carmichael P. , Tomlinson K. , Kumar S. , Baharani J. , Dasgupta I.
  • a Department of Renal Medicine, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom
  • b Department of Renal Medicine, University Hospitals Birmingham, Birmingham, United Kingdom
  • c Department of Renal Medicine, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom
  • d Department of Renal Medicine, Birmingham Heartlands Hospital, Birmingham, West Midlands, United Kingdom
  • e Department of Renal Medicine, University Hospitals Birmingham, Birmingham, United Kingdom
  • f Department of Renal Medicine, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom
  • g Department of Renal Medicine, University Hospitals Birmingham, Birmingham, United Kingdom
  • h Department of Renal Medicine, Royal Wolverhampton Hospitals, Wolverhampton, United Kingdom
  • i Department of Renal Medicine, North Staffordshire Hospitals, North Staffordshire, United Kingdom
  • j Department of Renal Medicine, Dudley Hospitals, Dudley, West Midlands, United Kingdom
  • k Department of Renal Medicine, Birmingham Heartlands Hospital, Birmingham, West Midlands, United Kingdom
  • l Department of Renal Medicine, Birmingham Heartlands Hospital, Birmingham, West Midlands, United Kingdom

Abstract

Introduction. Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis. Methods. Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IA patients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group. Results. In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001). Conclusion. IA patients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly. © 2010 by Lippincott Williams & Wilkins.

Author Keywords

Kidney transplantation overseas Outcomes

Index Keywords

China Asian kidney donor living donor Living Donors India survival rate follow up human hemodialysis patient Cohort Studies middle aged Asia cadaver donor travel controlled study priority journal Aged Great Britain Tissue and Organ Procurement Humans Adolescent graft survival male Treatment Outcome female Aged, 80 and over outcomes research clinical article Article adult kidney failure Kidney Transplantation United Kingdom crime composite graft
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954085985&doi=10.1097%2fTP.0b013e3181da6019&partnerID=40&md5=2476e06afc079dda68e266ea01b8835a
DOI: 10.1097/TP.0b013e3181da6019
ISSN: 00411337
Cited by: 21
Original Language: English