Methods: This was a retrospective chart-review study of the HBV vaccination records of all babies delivered at a district hospital in southern Taiwan from July 2008 to December 2011. There were a total of 7,931 mothers of whom 7,205 were Taiwanese and 726 were NIM. If mothers were HBsAg-positive, then information about maternal HBV markers, and the use of HBIG and HBV vaccines for newborns was collected. Chi-squared test, t-test and logistic regression were used for statistical analysis.Results: A total of 720 women (9.1%) were HBV carriers, and the carrier rates were 9.1% (653 mothers) for Taiwanese mothers and 9.2% (67 mothers) for NIM. Among carrier mothers, the HBeAg-positive rates were 21.1% (138) for Taiwanese mothers and 46.3% (31) for NIM including 24 from China and 7 from Vietnam. The multivariate logistic regression model found the odds ratio (OR) and 95% confidence interval (95% CI) for every increased year of maternal age was 0.87 (0.82-0.91, p = 0.001). The OR and 95%CI for NIM mothers was 2.59 (95% CI, 1.51-4.44, p < 0.001) compared to Taiwanese mothers. We followed 187 babies born to HBeAg-positive HBV carrier mothers, but found that only 30% had taken their babies to have their HBV status checked. Three of these were HBsAg-positive and another 4 were negative for both HBsAg and HBeAg. Two developed a positive antibody for HBsAg after receiving one dose of HBV vaccine.Conclusions: Among HBV carrier mothers, NIM had a twofold rate of being HBeAg-positive compared to Taiwanese mothers. The younger age and NIM were two significant risk factors for mothers to be HBeAg-positive. We suggest more education and encouragement for HBV carrier mothers to have their babies checked for HBV markers in order to find HBV infections earlier and to get another booster vaccine if there is no antibody.Objectives: To understand the hepatitis B virus (HBV) carrier rates among Taiwanese mothers and new immigrant mothers (NIM) as well as the results of their newborns receiving hepatitis B vaccine and immunoglobulin (HBIG).

Hepatitis B New immigrant mother Immunoglobulin Vaccine

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