High prevalence of clustered tuberculosis cases in Peruvian migrants in Florence, Italy

Infectious Disease Reports
Volume 6, Issue 4, 2014, Pages 45-47

High prevalence of clustered tuberculosis cases in Peruvian migrants in Florence, Italy (Article) (Open Access)

Zammarchi L. , Tortoli E. , Borroni E. , Bartalesi F. , Strohmeyer M. , Baretti S. , Simonetti M.T. , Liendo C. , Santini M.G. , Rossolini G.M. , Gotuzzo E. , Bartoloni A.* , Bonati M. , Pandolfini C. , Severino F. , Confalonieri V. , Tognoni G. , Bisoffi Z. , Buonfrate D. , Angheben A. , Albonico M. , Muñoz J. , Requena-Mendez A. , Roura M. , Ventura L. , Pool R. , Pell C. , Hardon A. , Chiodini P. , Moreira J. , Anselmi M. , Sempértegui R. , Mena M.A. , Garcia H.H. , Bustos J. , Santivañez S. , Torrico F. , Lozano D. , Cabrera T.H. , Morón J.O. , Cuellar I.A. , Suarez J.A. , Rojas G.C. , Nicoletti A. , Bruno E. , COHEMI project study group

^a Infectious Diseases Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Italy, Infectious Disease Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Florence, Italy
^b Emerging Bacterial Pathogens, IRCCS San Raffaele Scientific Institute, Milan, Italy
^c Emerging Bacterial Pathogens, IRCCS San Raffaele Scientific Institute, Milan, Italy
^d SOD Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
^e Infectious Diseases Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Italy, Infectious Disease Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Florence, Italy
^f UF Igiene e Sanità Pubblica, ASL 10 Zona Firenze, Florence, Italy
^g SOD Microbiologia e Virologia, Centro di Riferimento per i Micobatteri della Regione Toscana, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
^h Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Cayetano Heredia, Lima, Peru
ⁱ UF Igiene e Sanità Pubblica, ASL 10 Zona Firenze, Florence, Italy
^j SOD Microbiologia e Virologia, Centro di Riferimento per i Micobatteri della Regione Toscana, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
^k Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Cayetano Heredia, Lima, Peru
^l Infectious Diseases Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Italy, SOD Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria Careggi, Florence, Italy, Infectious Disease Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Florence, Italy
^m Department of Public Health, Laboratory for Mother and Child Health, 'Mario Negri' Pharmacological Research Institute, Milan, Italy
ⁿ Department of Public Health, Laboratory for Mother and Child Health, 'Mario Negri' Pharmacological Research Institute, Milan, Italy
^o Department of Public Health, Laboratory for Mother and Child Health, 'Mario Negri' Pharmacological Research Institute, Milan, Italy
^p Department of Public Health, Laboratory for Mother and Child Health, 'Mario Negri' Pharmacological Research Institute, Milan, Italy
^q Department of Public Health, Laboratory for Mother and Child Health, 'Mario Negri' Pharmacological Research Institute, Milan, Italy
^r Centre for Tropical Diseases, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy
^s Centre for Tropical Diseases, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy
^t Centre for Tropical Diseases, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy
^u Centre for Tropical Diseases, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy, Ivo de Carneri Foundation, Milano, Italy
^v Servicio de Medicina Tropical y Salud Internacional, Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^w Servicio de Medicina Tropical y Salud Internacional, Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^x Servicio de Medicina Tropical y Salud Internacional, Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^y Servicio de Medicina Tropical y Salud Internacional, Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^z Centre for Social Science and Global Health, University of Amsterdam, Netherlands
^a Centre for Social Science and Global Health, University of Amsterdam, Netherlands
^b Centre for Social Science and Global Health, University of Amsterdam, Netherlands
^c Hospital for Tropical Diseases and London School of Hygiene and Tropical Medicine, London, United Kingdom
^d Centre for Community Epidemiology and Tropical Medicine, Esmeraldas, Ecuador
^e Centre for Community Epidemiology and Tropical Medicine, Esmeraldas, Ecuador
^f Centre for Community Epidemiology and Tropical Medicine, Esmeraldas, Ecuador
^g Instituto de Medicina Tropical Alexander von Humboldt, Universidad Cayetano Heredia, Lima, Peru
^h Cysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
ⁱ Cysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
^j Cysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
^k Colectivo de Estudios Aplicados y Desarrollo Social, Cochabamba, Bolivia
^l Colectivo de Estudios Aplicados y Desarrollo Social, Cochabamba, Bolivia
^m Taller de Educacion y Comunicacion TEKOGUARANÌ, Camiri, Bolivia
ⁿ Taller de Educacion y Comunicacion TEKOGUARANÌ, Camiri, Bolivia
^o Taller de Educacion y Comunicacion TEKOGUARANÌ, Camiri, Bolivia
^p Taller de Educacion y Comunicacion TEKOGUARANÌ, Camiri, Bolivia
^q Taller de Educacion y Comunicacion TEKOGUARANÌ, Camiri, Bolivia
^r Dipartimento G.F. Ingrassia Sezione di Neuroscienze, Università di Catania, Catania, Italy
^s Dipartimento G.F. Ingrassia Sezione di Neuroscienze, Università di Catania, Catania, Italy
^t [Affiliation not available]

Abstract

Tuberculosis is a leading cause of morbidity for Peruvian migrants in Florence, Italy, where they account for about 20% of yearly diagnosed cases. A retrospective study on cases notified in Peruvian residents in Florence in the period 2001-2010 was carried out and available Mycobacterium tuberculosis strains were genotyped (MIRU-VNTR-24 and Spoligotyping). One hundred thirty eight cases were retrieved. Genotyping performed in 87 strains revealed that 39 (44.8%) belonged to 12 clusters. Assuming that in each cluster the transmission of tuberculosis from the index case took place in Florence, a large proportion of cases could be preventable by improving early diagnosis of contagious cases and contact tracing.

Author Keywords

immigrants Migrants Italy Peru tuberculosis Cluster Epidemiology

Index Keywords

interspersed repeat genotype human variable number of tandem repeat Mycobacterium tuberculosis nonhuman migrant Adolescent male female tuberculosis prevalence Article disease transmission major clinical study adult gene cluster Italy retrospective study Peruvian

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983435051&doi=10.4081%2fidr.2014.5646&partnerID=40&md5=1c05b55b22165cf8909c7ff577518951

DOI: 10.4081/idr.2014.5646

ISSN: 20367449

Cited by: 2

Original Language: English