American Journal of Tropical Medicine and Hygiene
Volume 52, Issue 6, 1995, Pages 479-484

Primaquine for prophylaxis against malaria among nonimmune transmigrants in Irian Jaya, Indonesia (Article)

Baird J.K. , Fryauff D.J. , Basri H. , Bangs M.J.* , Subianto B. , Wiady I. , Purnomo , Leksana B. , Masbar S. , Richie T.L. , Jones T.R. , Tjitra E. , Wignall F.S. , Hoffman S.L.
  • a Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • b Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • c Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • d Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • e Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • f Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • g Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • h Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • i Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • j Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • k Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • l Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • m Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
  • n Uniformed Serv. Univ. Hlth. Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States

Abstract

A comparison of primaquine versus chloroquine for prophylaxis among nonimmune transmigrants from Java and Bali in the hyperendemic Arso region of Irian Jaya, Indonesia was conducted. Forty-five subjects received 0.5 mg of primaquine base/kg of body weight every other day, and 54 people in the same village received weekly 5 mg of chloroquine base/kg for 16-19 weeks beginning in December 1992. Plasmodium falciparum accounted for 18 of 30 infections with chloroquine, and four of five infections among subjects receiving primaquine. Plasmodium vivax was found in 12 people taking chloroquine but in just one person taking primaquine. The risk of malaria among people taking chloroquine relative to that among subjects taking primaquine was 3.96 (P = 0.014) for P. falciparum and 10.56 (P = 0.012) for P. vivax. Primaquine was better tolerated than chloroquine. The minimal protective efficacy for primaquine prophylaxis was 74% against P. falciparum and 90% against P. vivax among nonimmune children and adults living in Irian Jaya. These findings require confirmation with randomized, double-blinded, and placebo-controlled trials.

Author Keywords

[No Keywords available]

Index Keywords

clinical trial human Malaria stomach pain oral drug administration drug efficacy malaise Adolescent headache Indonesia Article gastrointestinal symptom antibiotic prophylaxis infection prevention Parasitemia Plasmodium vivax fever primaquine major clinical study adult infection risk Plasmodium falciparum drug induced disease drug screening chloroquine Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029056637&doi=10.4269%2fajtmh.1995.52.479&partnerID=40&md5=d2bd1109d9f70a58679702f70df0948d
DOI: 10.4269/ajtmh.1995.52.479
ISSN: 00029637
Cited by: 69
Original Language: English