Gastric Cancer
Volume 21, Issue 4, 2018, Pages 588-597

Higher risk of gastric cancer among immigrants to Ontario: a population-based matched cohort study with over 2 million individuals (Article)

Sutradhar R.* , Asidianya N. , Lee F. , Coburn N. , Rabeneck L. , Paszat L.
  • a Department of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, Institute for Clinical Evaluative Sciences, G1-06 2075, Bayview Avenue, Toronto, ON M4N 3M5, Canada, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
  • b Department of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
  • c Institute for Clinical Evaluative Sciences, G1-06 2075, Bayview Avenue, Toronto, ON M4N 3M5, Canada, Department of Statistics, University of Waterloo, Waterloo, Canada
  • d Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada, Sunnybrook Research Institute, Toronto, Canada
  • e Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada, Sunnybrook Research Institute, Toronto, Canada, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada, Department of Medicine, University of Toronto, Toronto, Canada
  • f Institute for Clinical Evaluative Sciences, G1-06 2075, Bayview Avenue, Toronto, ON M4N 3M5, Canada, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada, Sunnybrook Research Institute, Toronto, Canada

Abstract

Background: The risk of gastric carcinoma (GC) varies around the world and between females and males. We aimed to compare the risk of GC among immigrants to Ontario, Canada, to the risk of GC in its general population. Methods: This was a retrospective population-based matched cohort study from 1991 to 2014. We identified immigrants who were first eligible for the Ontario Health Insurance Plan at age 40 years or older, and matched 5 controls by year of birth and sex. We calculated crude rates and relative rates of GC stratified by sex. We modeled GC hazard using multivariable Cox proportional hazards regression, where a time-varying coefficient was incorporated to examine changes in the association of immigrant status with GC hazard over time. Results: Among females, 415 GC cases were identified among 209,843 immigrants and 1872 among 1,049,215 controls. Among males, 596 GC cases were identified among 191,792 immigrants and 2998 among 958,960 controls. Comparing immigrants from East Asia and Pacific with the controls, the crude relative rate of GC was 1.54 for females and 1.32 for males. The adjusted hazard ratio (HR) for GC among female immigrants was 1.29 [95% confidence interval (CI) 1.12, 1.48] within 10 years and 1.19 (1.01, 1.40) beyond 10 years; for males, the HR was 1.17 (1.04, 1.31) within 10 years and 1.00 (0.87, 1.15) beyond 10 years. Conclusion: The risk of GC among immigrants is elevated. Although high-risk immigrant populations in Ontario have been identified, further knowledge is required before a program of GC prevention that is targeted to them can be planned. © 2017, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.

Author Keywords

immigrants Relative rate Gastric cancer Cox regression model with time-varying coefficient Matched cohort study

Index Keywords

immigrant human middle aged statistics and numerical data controlled study priority journal East Asian Aged cancer risk Far East stomach tumor hazard ratio Stomach Neoplasms Humans migrant male Emigrants and Immigrants female risk factor Risk Factors high risk population Article Ontario major clinical study adult age distribution cohort analysis Case-Control Studies retrospective study case control study stomach cancer
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039556730&doi=10.1007%2fs10120-017-0790-x&partnerID=40&md5=6eb3c870537a0dfaf12fd6fba884e418
DOI: 10.1007/s10120-017-0790-x
ISSN: 14363291
Original Language: English