International Journal of Tuberculosis and Lung Disease
Volume 2, Issue 8, 1998, Pages 641-646

Outcome of first-line tuberculosis treatment in migrants from Vietnam (Article)

Bollini P.* , Pampallona S. , O'Rourke T. , Jones W. , Truong T.B. , Nguyen H.P. , Bang L.C. , An D.Q. , Keane V.P. , Siem H. , Gushulak B.
  • a ForMed, 1983 Evolène, Switzerland
  • b [Affiliation not available]
  • c [Affiliation not available]
  • d IOM, Ho-Chi-Minh City
  • e IOM, Ho-Chi-Minh City
  • f IOM, Ho-Chi-Minh City
  • g 30th April Hospital, Ho-Chi-Minh City
  • h Cho Ray Hospital, Ho-Chi-Minh City
  • i IOM, Harare
  • j IOM, Geneva
  • k IOM, Geneva

Abstract

SETTING: Screening and treatment of tuberculosis in prospective migrants from Vietnam, in the framework of the Orderly Departure Programme. OBJECTIVE: 1) To describe the outcome of first-line tuberculosis treatment, and 2) to investigate the role of prognostic factors on treatment outcome. DESIGN: Cohort of consecutive smear-positive patients identified by screening before departure, and followed up until cure or failure, for a maximum of two years. RESULTS: Seven hundred and twenty-nine patients were consecutively diagnosed with infectious tuberculosis. Patients received directly observed treatment with rifampicin, isoniazid, ethambutol and pyrazinamide for a minimum of 6 months, or until sputum conversion was maintained for 6 consecutive months. The cumulative percentage of cure with first-line treatment was 50.2% (SE = 2%) at 7 months, and 92.8% (SE = 2%) at 24 months. Young patients without cavities achieved the highest percentage of cure. Stratified testing confirmed the negative effect on the chance of cure of age >45 years (P < 0.001), and cavities (P < 0.001), while the effect of previous treatment was not significant (P = 0.105). CONCLUSIONS: While the overall cure rate was satisfactory, older patients and those with cavities required prolonged treatment and reached a less satisfactory level of cure.

Author Keywords

Immigrants and emigrants Vietnam tuberculosis

Index Keywords

Vietnam sputum smear human middle aged priority journal Aged Time Factors prognosis screening health program Humans tuberculostatic agent Antitubercular Agents Adolescent Treatment Outcome Tuberculosis, Pulmonary male Aged, 80 and over Viet Nam tuberculosis female prevalence Article major clinical study adult migration isoniazid tuberculosis control ethambutol Transients and Migrants rifampicin pyrazinamide Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-7344245461&partnerID=40&md5=7e06142e6b685ced446f147aed4fb12e
ISSN: 10273719
Cited by: 6
Original Language: English