Journal of Parasitology
Volume 83, Issue 6, 1997, Pages 1174-1177

Adaptation of a strain of Plasmodium falciparum from a Montagnard refugee to Aotus monkeys (Article)

Collins W.E. , Grady K.K. , Millet P.* , Sullivan J.S. , Morris C.L. , Galland G.G. , Richardson B.B. , Yang C.
  • a Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States
  • b Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States
  • c Intl. Center for Medical Research, BP 769, Franceville, Gabon, Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States
  • d Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States
  • e Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States
  • f Div. Parasitic Dis. Sci. Rsrc. Prog., Public Health Service, Dept. of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, United States
  • g Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States
  • h Natl. Center for Infectious Diseases, Centers for Dis. Contr. and Prev., Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, United States

Abstract

A strain of Plasmodium falciparum from a Montagnard refugee was shown to produce large numbers of gametocytes in culture. Attempts were made to establish this strain in Aotus monkeys via trophozoite and sporozoite inoculation. The Montagnard S-1 strain was readily adapted to A. l. griseimembra monkeys via trophozoite inoculation. Other species of Aotus failed to support the development of high density parasitemia. None of 12 attempts to transmit the infection via sporozoites from Anopheles freeborni or An. dirus mosquitoes was successful; however, developing exoerythrocytic stages were demonstrated in hepatocytes of an A. lemurinus griseimembra monkey.

Author Keywords

[No Keywords available]

Index Keywords

Vietnam parasitology Species Specificity trophozoite Saimiri Serial Passage Aotus lemurinus sporozoite Anopheles freeborni Aotidae monkey human Anopheles Malaria Animals nonhuman school child Humans case report female Protozoa Animalia Article Adaptation, Physiological disease transmission animal experiment Malaria, Falciparum Plasmodium falciparum Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031440013&doi=10.2307%2f3284381&partnerID=40&md5=ad28a50c3ad303e5cae2e22dd5e3161e
DOI: 10.2307/3284381
ISSN: 00223395
Cited by: 6
Original Language: English