Clinical Genetics
Volume 52, Issue 3, 1997, Pages 142-146

Consanguineous marriage and its clinical consequences in migrants to Australia (Article)

Nelson J.* , Smith M. , Bittles A.H.
  • a Clinical Genetics Unit, Westmead Hospital, Sydney, NSW, Australia, Genetic Serv. of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Perth, WA 6008, Australia
  • b Clinical Genetics Unit, Westmead Hospital, Sydney, NSW, Australia
  • c Centre for Human Genetics, Edith Cowan University, Perth, WA, Australia

Abstract

Marriage between close biological relatives is strongly favoured in many countries in Asia and Africa. Although substantial numbers of migrants from these regions are now living in Australia, little information is available either on the prevalence of consanguineous unions among migrants or on their clinical outcome. Data are presented on a range of generally rare autosomal recessive genetic disorders diagnosed in the children of parents of Eastern Mediterranean origin who attended Westmead Hospital, Sydney for genetic counselling during the period 1990 to 1994. The effects of parental consanguinity are assessed both in terms of the specific recessive disorders detected, and the perceived role of consanguineous marriage in the communities investigated.

Author Keywords

Australia Migrants Eastern Mediterranean Autosomal recessive disorders Consanguineous

Index Keywords

immigrant Australia Follow-Up Studies community human consanguineous marriage Chromosome Disorders Abnormalities autosomal recessive disorder priority journal Chromosome Aberrations Genes, Recessive Humans male female consanguinity prevalence Article major clinical study Emigration and Immigration genetic counseling relative genetic disorder
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030807459&partnerID=40&md5=efbd37a7aad8dc14aa94ef0f4d8c2224
ISSN: 00099163
Cited by: 16
Original Language: English