Infection, Genetics and Evolution
Volume 71, 2019, Pages 159-165

Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal: Implications at the public health level (Article)

Pereira C. , Gomes P. , Taveira R. , Silva C. , Maltez F. , Macedo R. , Costa C. , Couvin D. , Rastogi N. , Viveiros M. , Perdigão J.* , Portugal I.
  • a Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
  • b Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
  • c Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
  • d Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
  • e Serviço de Doenças Infecciosas, Hospital de Curry Cabral, Lisboa, Portugal
  • f Departamento de Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal
  • g Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
  • h WHO Supranational TB Reference Laboratory, Tuberculosis and Mycobacteria Unit, Institut Pasteur de la Guadeloupe, Morne Jolivière AbymesGuadeloupe, France
  • i WHO Supranational TB Reference Laboratory, Tuberculosis and Mycobacteria Unit, Institut Pasteur de la Guadeloupe, Morne Jolivière AbymesGuadeloupe, France
  • j Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal
  • k Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
  • l Research Institute of Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal

Abstract

Tuberculosis among foreign-born patients is a key indicator of country-level epidemiological profiles and, of an increasing concern in Europe given the more intensified migratory waves of refugees. Since Portugal presents a lower immigrant-associated TB incidence rate when compared to other European countries, we sought to characterize the epidemiology and transmission dynamics among the foreign-born population coming from Portuguese-speaking countries that are associated with higher TB incidences. In the present study we analyzed 133 Mycobacterium tuberculosis isolates obtained from foreign-born individuals over a three-year period in Lisbon, Portugal, using molecular epidemiological methods such as spoligotyping and 24-loci MIRU-VNTR. Moreover, all strains were subjected to drug susceptibility testing. The genetic profiles obtained suggest that strain importation from Portuguese speaking countries plays a less important role in TB epidemiology but instead argue in favor of a high degree of penetrance of Portuguese endemic strains to the migrant population, including multidrug resistant strains, which is particularly relevant to active screening programs. © 2019 Elsevier B.V.

Author Keywords

Migrants Spoligotyping M. Tuberculosis Lisboa3 RDRio MIRU-VNTR

Index Keywords

quinoline derived antiinfective agent Portuguese (language) molecular epidemiology capreomycin Portugal bacterium isolation bacterium identification human controlled study variable number of tandem repeat Mycobacterium tuberculosis priority journal population structure nonhuman ofloxacin migrant tuberculosis genetic profile gene locus Article streptomycin antibiotic sensitivity ethambutol bacterial strain pyrazinamide public health
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063727173&doi=10.1016%2fj.meegid.2019.03.025&partnerID=40&md5=33ddec34ca2e93ef52df1e2be3a8900f
DOI: 10.1016/j.meegid.2019.03.025
ISSN: 15671348
Original Language: English