Travel Medicine and Infectious Disease
Volume 29, 2019, Pages 40-47

Travel-related health events and their risk factors in HIV-infected sub-Saharan migrants living in France and visiting their native country: The ANRS VIHVO cohort study (Article) (Open Access)

Pistone T.* , Ouattara E. , Gabillard D. , Lele N. , Duvignaud A. , Cordel H. , Malvy D. , Bouchaud O. , Abgrall S. , Bentata M. , Fantin B. , Goujard C. , Matheron S. , Launay O. , Le Moing V. , Lortholary O. , Consigny P.-H. , Saada M. , Katlama C. , Simon A. , Arvieux C. , Campa P. , Girard P.-M. , Khuong M.-A. , Molina J.-M. , Lascoux-Combe C. , Rey D. , Rondeau M. , Pialoux G. , Couzigou C. , Vittecoq D. , Patey O. , Morlat P. , Duong M. , Chavanet P. , ANRS VIHVO Study Group
  • a CHU Bordeaux, Department for Infectious and Tropical Diseases, Bordeaux, 33000, France, Inserm U1219, Infectious Diseases in Lower Income Countries (IDLIC), Université de Bordeaux, 146 rue Léo-Saignat, Bordeaux cedex, 33076, France
  • b CHU Bordeaux, Department for Infectious and Tropical Diseases, Bordeaux, 33000, France, Inserm U1219, Infectious Diseases in Lower Income Countries (IDLIC), Université de Bordeaux, 146 rue Léo-Saignat, Bordeaux cedex, 33076, France
  • c Inserm U1219, Infectious Diseases in Lower Income Countries (IDLIC), Université de Bordeaux, 146 rue Léo-Saignat, Bordeaux cedex, 33076, France
  • d AP-HP, Service des Maladies Infectieuses et Tropicales, Hôpital Avicenne, Bobigny, 93000, France, Université Paris 13, Bobigny, France
  • e CHU Bordeaux, Department for Infectious and Tropical Diseases, Bordeaux, 33000, France, Inserm U1219, Infectious Diseases in Lower Income Countries (IDLIC), Université de Bordeaux, 146 rue Léo-Saignat, Bordeaux cedex, 33076, France
  • f AP-HP, Service des Maladies Infectieuses et Tropicales, Hôpital Avicenne, Bobigny, 93000, France, Université Paris 13, Bobigny, France
  • g CHU Bordeaux, Department for Infectious and Tropical Diseases, Bordeaux, 33000, France, Inserm U1219, Infectious Diseases in Lower Income Countries (IDLIC), Université de Bordeaux, 146 rue Léo-Saignat, Bordeaux cedex, 33076, France
  • h AP-HP, Service des Maladies Infectieuses et Tropicales, Hôpital Avicenne, Bobigny, 93000, France, Université Paris 13, Bobigny, France
  • i AP-HP, Hôpital Antoine Béclère, Clamart, France, Inserm U1018, Centre de recherche en Epidémiologie et Santé des Populations (CESP), Le Kremlin-Bicêtre Cedex, Université Paris Sud University, Paris Saclay University, France
  • j CHU Avicenne, Bobigny, France
  • k CHU Beaujon, Clichy, France
  • l CHU Bicêtre, Le Kremlin-Bicêtre, France
  • m CHU Bichat, Paris, France
  • n CHU Cochin, Paris, France
  • o CHU de Montpellier, Montpellier, France
  • p CHU Necker, Paris, France
  • q CHU Pasteur, Paris, France
  • r Hôpital de Perpignan, Perpignan, France
  • s CHU Pitié-Salpétrière, Paris, France
  • t CHU Pitié-Salpétrière, Paris, France
  • u CHU de Rennes, Rennes, France
  • v CHU Saint-Antoine, Paris, France
  • w CHU Saint-Antoine, Paris, France
  • x Hôpital De Lafontaine, Saint- Denis, France
  • y CHU Saint-Louis, Paris, France
  • z CHU Saint-Louis, Paris, France
  • a Hôpital Civil, Strasbourg, France
  • b Hôpital Civil, Strasbourg, France
  • c CHU Tenon, Paris, France
  • d CHU Paul Brousse, Villejuif, France
  • e CHU Paul Brousse, Villejuif, France
  • f Hôpital de Villeneuve Saint Georges, Villeneuve saint Georges, France
  • g CHU Bordeaux, Bordeaux, France
  • h CHU Dijon, Dijon, France
  • i CHU Dijon, Dijon, France
  • j [Affiliation not available]

Abstract

Background: Literature on health events in HIV-infected travellers is scarce, particularly in sub-Saharan African (SSA) migrants. Methods: We investigated health events in HIV-infected SSA migrants living in France during and after travel to their native country. All had a pre-travel plasma viral load (pVL) below 200 copies/mL and were on stable combined antiretroviral therapy (cART). Logistic regression models were used to assess the risk factors for at least one adverse health event or febrile event. Results: Among 264 HIV migrants, pre-travel median CD4 count was 439/mm3 and 27 migrants (6%) experienced a low-level viremia between 50 and 200 copies/mL. One hundred (38%) experienced at least one event (13 experienced two events). The most common events were gastrointestinal, including diarrhoea (n = 29, 26%), respiratory events (n = 20, 18%), and malaria (n = 17, 15%; 1 death). In multivariable analysis, a pre-travel low-level viremia and a lack of pre-travel medical advice significantly increased the risk for any event (OR 4.31, 95% CI, 1.41–13.1; and OR 3.62, 95% CI, 1.38–9.47; respectively). A lack of pre-travel advice significantly increased the risk for febrile event. Conclusions: Early and tailored counselling on pre-travel medical advice regarding diarrhoea and vector-borne diseases prophylactic measures in HIV-infected SSA migrants should be emphasised before travel to Africa. © 2019 The Authors

Author Keywords

Sub-Saharan Africa HIV infection travel Health event migrant visiting friends and relatives

Index Keywords

Gastrointestinal Diseases HIV Infections Africa south of the Sahara Human immunodeficiency virus infection logistic regression analysis France human Respiratory Tract Diseases Odds Ratio travel related disease gastrointestinal disease Viral Load statistics and numerical data priority journal Malaria Anti-Retroviral Agents antiretrovirus agent respiratory tract disease ethnology Confidence interval Humans migrant virology male CD4 lymphocyte count female risk factor Multivariate Analysis Risk Factors diarrhea Article major clinical study adult fever migration antiretroviral therapy virus load cohort analysis Transients and Migrants Travel-Related Illness mortality anti human immunodeficiency virus agent
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064468371&doi=10.1016%2fj.tmaid.2019.03.010&partnerID=40&md5=cb169040f5d4ed11eaf4d5bddd2851f7
DOI: 10.1016/j.tmaid.2019.03.010
ISSN: 14778939
Cited by: 1
Original Language: English