Journal of Medical Virology
Volume 91, Issue 3, 2019, Pages 385-391
Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections (Article)
Wu X. ,
Lu X. ,
Schneider E. ,
Ahmed J.A. ,
Njenga M.K. ,
Breiman R.F. ,
Eidex R.B. ,
Erdman D.D.*
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a
Department of Microbiology, Guangzhou Center for Disease Control and Prevention, Guangzhou, China
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b
Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, Georgia
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c
Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, Georgia
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d
Surveillance, Lab and Data (SLD), Polio Eradication, World Health Organization, Geneva, Switzerland
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e
Washington State University Global Health - Kenya, Washington State University, Pullman, WA, United States
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f
Emory Global Health Institute, Emory University, Atlanta, GA, Georgia
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g
Division of Global Migration and Quarantine, Centers for Disease Control and Prevention (CDC), Atlanta, GA, Georgia
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h
Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, Georgia
Abstract
Human adenoviruses (HAdVs) were previously detected at high prevalence by real-time reverse transcription-polymerase chain reaction (rRT-PCR) in the upper respiratory tract of residents of two Kenyan refugee camps under surveillance for acute respiratory infection (ARI) between October 2006 and April 2008. We sought to confirm this finding and characterize the HAdVs detected. Of 2148 respiratory specimens originally tested, 511 (23.8%) screened positive for HAdV and 510 were available for retesting. Of these, 421 (82.4%) were confirmed positive by repeat rRT-PCR or PCR and sequencing. Other respiratory viruses were codetected in 55.8% of confirmed HAdV-positive specimens. Species B and C viruses predominated at 82.8%, and HAdV-C1, -C2, and -B3 were the most commonly identified types. Species A, D, and F HAdVs, which are rarely associated with ARI, comprised the remainder. Viral loads were highest among species B HAdVs, particularly HAdV-B3. Species C showed the widest range of viral loads, and species A, D, and F were most often present at low loads and more often with codetections. These findings suggest that many HAdV detections were incidental and not a primary cause of ARI among camp patients. Species/type, codetections, and viral load determinations may permit more accurate HAdV disease burden estimates in these populations. © 2018 Wiley Periodicals, Inc.
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056158744&doi=10.1002%2fjmv.25320&partnerID=40&md5=8ba9329f0cb95d420f3027ab54f48aca
DOI: 10.1002/jmv.25320
ISSN: 01466615
Cited by: 1
Original Language: English