Travel Medicine and Infectious Disease
Volume 28, 2019, Pages 59-63

Performance of the point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for follow-up after treatment of S. mansoni infection in Eritrean refugees (Article)

Neumayr A.* , Chernet A. , Sydow V. , Kling K. , Kuenzli E. , Marti H. , Paris D.H. , Nickel B. , Labhardt N.D.
  • a Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • b Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • c Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • d Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • e Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • f Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • g Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • h Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
  • i Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland

Abstract

Background: Point-of-care circulating cathodic antigen (POC-CCA) urine cassette testing has become a popular approach to screen for Schistosoma infection. Since the test is also increasingly used for following-up of treatment success, we assessed the assay's diagnostic accuracy after praziquantel treatment of S. mansoni infection among Eritrean refugees in Switzerland. Methods: In our preceding study, 107 asymptomatic Eritrean refugees in Switzerland were screened for schistosomiasis by stool microscopy, serology, and POC-CCA urine testing. Individuals screened positive by any method were treated with praziquantel and invited for a follow-up visit, repeating the same diagnostic procedures one year after treatment. The POC-CCA baseline and follow-up results were analyzed against the ‘baseline microscopy positive cases’ (= the most reliably true positive cases) and the ‘baseline microscopy plus serology negative cases at baseline and follow-up’ (= the most reliably true negative cases). Results: Complete diagnostic baseline and follow-up sampling was available from 48 participants. Compared to most reliably true positive cases at baseline, POC-CCA testing had a sensitivity of 90%. Compared to most reliably true negative cases, POC-CCA testing had a specificity of 73.9%. Conclusion: We conclude that the POC-CCA urine test is valuable for screening but its use is not suitable for routine follow-up after treatment. © 2018

Author Keywords

Screening Urine Migrants Specificity Schistosomiasis

Index Keywords

parasitology Eritrea refugee Follow-Up Studies follow up human Refugees feces analysis diagnostic accuracy priority journal Animals animal Young Adult cross-sectional study Humans point of care system antiparasitic therapy circulating cathodic antigen urine cassette testing Point-of-Care Systems male Schistosoma mansoni performance female reliability reproducibility schistosomiasis mansoni Reproducibility of Results evaluation study standards sensitivity and specificity blood examination Hematologic Tests Article blood Eritrean major clinical study adult Feces serology microscopy diagnostic procedure praziquantel point of care testing Urinalysis urine Switzerland
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053682685&doi=10.1016%2fj.tmaid.2018.09.004&partnerID=40&md5=ca9b5143c7cc148726be6858d5501b6b
DOI: 10.1016/j.tmaid.2018.09.004
ISSN: 14778939
Cited by: 3
Original Language: English